--- title: "P-Shot (PRP) for ED in Edmonton & Calgary | ReGenesis" description: "P-Shot (Priapus Shot) PRP therapy for erectile dysfunction — how it works, expected results and availability at ReGenesis Edmonton and Calgary." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": [ "Article", "MedicalWebPage" ], "headline": "P-Shot (PRP) for ED: Edmonton & Calgary Guide", "description": "P-Shot (Priapus Shot) PRP therapy for erectile dysfunction — how it works, expected results and availability at ReGenesis Edmonton and Calgary.", "datePublished": "2025-06-28", "dateModified": "2025-06-28", "inLanguage": "en-CA", "mainEntityOfPage": { "@type": "WebPage", "@id": "https://regenesisformen.com/blog/p-shot-prp-therapy-ed-edmonton-calgary" }, "author": { "@type": "Person", "name": "Dr. Lloyd Tapper, PhD, NP", "jobTitle": "Nurse Practitioner, Founder", "honorificPrefix": "Dr.", "honorificSuffix": "PhD, NP", "affiliation": { "@type": "MedicalOrganization", "name": "ReGenesis Longevity Clinic" } }, "reviewedBy": { "@type": "Person", "name": "Dr. Lloyd Tapper, PhD, NP", "honorificSuffix": "PhD, NP", "jobTitle": "Nurse Practitioner, Founder" }, "publisher": { "@type": "MedicalOrganization", "name": "ReGenesis Longevity Clinic", "areaServed": [ "Edmonton", "Calgary", "Alberta", "Canada" ] }, "medicalAudience": { "@type": "MedicalAudience", "audienceType": "Patient", "geographicArea": { "@type": "AdministrativeArea", "name": "Alberta, Canada" } }, "about": { "@type": "MedicalCondition", "name": "Erectile Dysfunction" }, "image": { "@type": "ImageObject", "url": "https://regenesisformen.com/assets/hero-pshot-prp-Xnc-q7Cz.jpg", "width": 1600, "height": 900 }, "keywords": "Men's Health, erectile dysfunction, ED treatment, Edmonton, Calgary, Alberta, men's health, ReGenesis Longevity Clinic", "articleSection": "Men's Health" }, { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://regenesisformen.com/" }, { "@type": "ListItem", "position": 2, "name": "Blog", "item": "https://regenesisformen.com/blog" }, { "@type": "ListItem", "position": 3, "name": "P-Shot (PRP) for ED: Edmonton & Calgary Guide", "item": "https://regenesisformen.com/blog/p-shot-prp-therapy-ed-edmonton-calgary" } ] } ] --- [![ReGenesis Longevity Clinic](/assets/regenesis-logo-WRupJqE0.png)](/) [Home](/)[Treatments](/#solutions)[About](/#about)[Reviews](/#reviews)[Blog](/blog)[Contact](/#contact) [587.635.3414](tel:587.635.3414) [Back to Blog](/blog) Men's Health June 28, 2025 12 min read # P-Shot (PRP) for ED: Edmonton & Calgary Guide ![P-Shot (PRP) for ED: Edmonton & Calgary Guide — ReGenesis Longevity Clinic, Edmonton & Calgary](/assets/hero-pshot-prp-Xnc-q7Cz.jpg) P-Shot (PRP) for ED: Edmonton & Calgary Guide Share This Article ## P-Shot (Priapus Shot): Regenerative Medicine for Erectile Dysfunction Regenerative medicine represents one of the most promising frontiers in erectile dysfunction treatment. Among regenerative approaches, the P-Shot — formally known as the Priapus Shot — has gained significant attention for its use of autologous platelet-rich plasma (PRP) to stimulate tissue repair, neovascularization, and functional improvement in the penis. At ReGenesis clinics in Edmonton and Calgary, the P-Shot is offered as part of our comprehensive treatment toolkit — used both as a standalone therapy for mild-to-moderate ED and as a complement to other treatments for enhanced outcomes. \> "Regenerative medicine isn't science fiction — it's current clinical practice. PRP has been used in orthopedics, wound healing, and dermatology for decades. Applying it to erectile dysfunction is a logical extension of the same principles: concentrate the body's own healing factors and deliver them where they're needed." > — **Dr. Lloyd Tapper, PhD, NP — Founder, ReGenesis** ## What Is Platelet-Rich Plasma (PRP)? PRP is a concentration of platelets derived from the patient's own blood. Platelets contain granules loaded with **growth factors** — signaling proteins that orchestrate tissue repair processes: - **Platelet-Derived Growth Factor (PDGF)**: Stimulates cell proliferation and angiogenesis - **Vascular Endothelial Growth Factor (VEGF)**: Promotes new blood vessel formation - **Transforming Growth Factor-β (TGF-β)**: Regulates tissue remodeling and collagen synthesis - **Epidermal Growth Factor (EGF)**: Stimulates cell growth and differentiation - **Insulin-Like Growth Factor (IGF-1)**: Supports tissue growth and repair - **Fibroblast Growth Factor (FGF)**: Stimulates endothelial cell proliferation and smooth muscle regeneration By concentrating platelets to 3–8 times their normal blood concentration, PRP delivers a supraphysiological dose of growth factors to the target tissue — in this case, the corpus cavernosum of the penis. ## The Science Behind PRP for ED ### Mechanism of Action When injected into the corpus cavernosum, PRP initiates several biological processes relevant to erectile function recovery: 1. **Angiogenesis**: Growth factors stimulate the formation of new capillaries and arterioles, improving blood supply to the penile tissue. This is particularly relevant for vasculogenic ED, where reduced blood flow is the primary pathology. 1. **Smooth muscle regeneration**: The corpus cavernosum is composed predominantly of smooth muscle. ED is associated with progressive smooth muscle loss and replacement with fibrotic tissue. PRP growth factors promote smooth muscle cell proliferation and reduce fibrosis (Ding et al., 2016, _Andrologia_). 1. **Nerve trophic effects**: Growth factors including NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) present in PRP may support nerve repair — relevant for neurogenic ED following prostatectomy or diabetic neuropathy. 1. **Endothelial repair**: PRP growth factors recruit and activate endothelial progenitor cells, supporting repair of the damaged endothelial lining that is central to ED pathophysiology. ### Clinical Evidence The evidence base for PRP in ED is growing, with several published studies demonstrating benefit: **Epifanova et al. (2020, _Sexual Medicine Reviews_)** A systematic review of PRP for ED identified multiple studies showing statistically significant improvements in IIEF (International Index of Erectile Function) scores. The authors concluded that PRP represents a "promising therapeutic option" for ED, while noting the need for larger randomized controlled trials. **Ruffo et al. (2020, _Translational Andrology and Urology_)** A prospective study of 60 men with vasculogenic ED treated with PRP reported significant improvement in IIEF-EF domain scores at 1, 3, and 6 months post-treatment. Peak improvement occurred at 3 months. **Scott et al. (2019, _Journal of Sexual Medicine_)** A pilot study combining PRP with low-intensity shockwave therapy (LiSWT) showed synergistic improvement in erectile function scores — greater than either treatment alone — suggesting that combination regenerative approaches may optimize outcomes. \> "The evidence for PRP in ED is promising and growing. We're not claiming it's a miracle cure — we're saying it's a clinically legitimate regenerative treatment that offers meaningful improvement for the right patients, especially when combined with other therapies." > — **Dr. Lloyd Tapper, PhD, NP** ## The P-Shot Procedure at ReGenesis ### Pre-Procedure - Medical history review and confirmation of suitability - Baseline IIEF score documentation - Informed consent discussion covering expected outcomes, timelines, and limitations ### Step 1: Blood Draw A small volume of blood (typically 30–60 mL) is drawn from the patient's arm — similar to a routine blood test. ### Step 2: PRP Preparation The blood sample is processed in a centrifuge to separate and concentrate the platelet-rich fraction. This process takes approximately 10–15 minutes. ### Step 3: Topical Anesthesia A numbing cream (lidocaine-based) is applied to the penis for 15–20 minutes to minimize discomfort during injection. ### Step 4: PRP Injection Using a fine-gauge needle, the concentrated PRP is injected into specific areas of the corpus cavernosum and, in some protocols, the glans penis. The injection itself takes approximately 5–10 minutes. ### Step 5: Post-Procedure - Most men return to normal activities immediately - Sexual activity can typically resume within 24–48 hours - Mild swelling or bruising may occur and resolves within a few days ### Total Appointment Time: 45–60 minutes ## Expected Results and Timeline PRP works through biological regeneration — not pharmacological action — so results develop gradually: - **2–4 weeks**: Initial improvement in sensation and early morning erections reported by some men - **4–8 weeks**: Progressive improvement in erectile firmness and duration - **8–12 weeks**: Peak improvement, with continued gains possible - **12–18 months**: Duration of benefit before repeat treatment may be considered ### Who Responds Best? Based on clinical experience and published data, the best P-Shot candidates include: - Men with **mild-to-moderate vasculogenic ED** — enough residual vascular capacity to respond to enhanced blood flow - Men with **Peyronie's disease** — PRP may reduce plaque-associated fibrosis and improve curvature - Men seeking to **enhance PDE5 inhibitor response** — PRP can improve the vascular substrate that medications act upon - Men with **reduced penile sensitivity** — growth factors may support sensory nerve recovery - Men who **prefer non-pharmaceutical approaches** or want to reduce medication dependence ### Who May Not Respond - Men with **severe atherosclerotic vascular disease** — insufficient residual vasculature for regeneration - Men with **complete neurogenic ED** — nerve damage beyond regenerative capacity - Men expecting **immediate results** — PRP requires weeks to months for biological effect ## P-Shot as Part of a Combination Strategy At ReGenesis, the P-Shot is often most effective when combined with complementary treatments: Combination Rationale **P-Shot + Shockwave therapy** Synergistic neovascularization; studies suggest enhanced outcomes \_(Note: P-Shot with Shockwave is not provided at ReGenesis Longevity Clinic.)\_ **P-Shot + Daily tadalafil** PRP regenerates tissue; tadalafil maintains blood flow and NO signaling **P-Shot + Testosterone optimization** Hormonal optimization supports tissue responsiveness to growth factors **P-Shot + Lifestyle modification** Cardiovascular improvement amplifies vascular regeneration ## Safety Profile The P-Shot has an excellent safety profile, primarily because PRP is autologous — derived from the patient's own blood, eliminating risks of allergic reaction or immune rejection. **Reported side effects** (all temporary): - Mild pain or discomfort at injection site (resolves within hours) - Minor bruising or swelling (resolves within days) - Temporary numbness from topical anesthesia **Serious complications**: None reported in the published literature for penile PRP injection. ## Cost and Accessibility The P-Shot is available at both our **Edmonton (Windermere Plaza)** and **Calgary (Silk Touch)** locations. As a regenerative treatment, it is not covered by most private insurance plans. Detailed pricing is provided during the consultation, and receipts are issued for potential medical expense claims. ## References 1. Epifanova MV, et al. Platelet-rich plasma therapy for male sexual dysfunction: myth or reality? _Sexual Medicine Reviews_. 2020;8(1):106-113. 2. Ruffo A, et al. Effectiveness of platelet-rich plasma for the treatment of erectile dysfunction: a systematic review. _Translational Andrology and Urology_. 2020;9(Suppl 1):S56-S63. 3. Scott S, et al. Platelet-rich plasma and erectile dysfunction: a pilot study. _Journal of Sexual Medicine_. 2019;16(S2):S44-S45. 4. Ding XG, et al. Effect of platelet-rich plasma on the regeneration of corpus cavernosum smooth muscle cells. _Andrologia_. 2016;48(1):39-44. 5. Matz EL, et al. Stem cell and gene-based therapy for erectile dysfunction. _Translational Andrology and Urology_. 2019;8(Suppl 1):S14-S19. ## Schedule Your Assessment Location Address Phone Action **Edmonton — Windermere Plaza** 213, 5540 Windermere Blvd, Edmonton, AB T6W 2Z8 587.635.3414 **[Book Now →](/contact)** **Calgary — Silk Touch** 1102, 8561 8A Ave SW, Calgary, AB T3H 0V5 403.454.8196 **[Book Now →](/contact)** _Confidential assessments available. Same-week appointments for new patients._ ### Ready to Take the Next Step? Book a confidential assessment with a ReGenesis clinician. [Call 587.635.3414](tel:587.635.3414) ## Protect Your Health. Restore Your Vitality. Erectile dysfunction is your body's early warning system. Don't ignore it — optimize it. Book your comprehensive assessment today. [Schedule Your Assessment →](/contact) ![ReGenesis Longevity Clinic](/assets/regenesis-logo-footer-S7t4U9jL.png) Men's Vitality & Performance. 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