---
title: "Best ED Treatments in Edmonton & Calgary | ReGenesis"
url: https://regenesisformen.com/blog/best-ed-treatment-options-edmonton-calgary
description: "Compare every ED treatment available at ReGenesis Edmonton and Calgary — oral medications, P-Shot, Trimix, shockwave and penile implants."
lang: en
---

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Men's Health July 14, 2025 14 min read

# Best ED Treatment Options in Edmonton & Calgary

Image: Best ED Treatment Options in Edmonton & Calgary — ReGenesis Longevity Clinic, Edmonton & Calgary (https://regenesisformen.com/assets/hero-best-ed-treatments-CdOTaASO.jpg)

Best ED Treatment Options in Edmonton & Calgary

## A Comprehensive Guide to ED Treatment in Alberta

Erectile dysfunction treatment has evolved dramatically over the past three decades. What was once limited to psychotherapy, vacuum devices, and invasive surgery now encompasses a sophisticated treatment ladder — from precision-dosed oral medications and injectable therapies to regenerative medicine and state-of-the-art surgical implants.

At ReGenesis, our Edmonton (Windermere Plaza) and Calgary (Silk Touch) clinics offer the complete spectrum of evidence-based ED treatments. This guide provides a detailed, research-backed overview of every option available.

\> "The most important thing I tell patients is this: there is a solution for every man. The question isn't whether we can restore your function — it's which approach is the best fit for your body, your health profile, and your goals." > — **Dr. Lloyd Tapper, PhD, NP — Founder, ReGenesis**

## Understanding the Treatment Ladder

Modern ED treatment follows a stepped approach, progressing from least invasive to most invasive based on individual response. This framework — endorsed by the American Urological Association (AUA), the European Association of Urology (EAU), and the Canadian Urological Association (CUA) — ensures that every patient receives the most appropriate treatment with the fewest side effects.

The key principle: **you don't skip steps, but you don't stay on a step that isn't working.**

## Tier 1: Lifestyle Optimization — The Foundation

### The Evidence

Lifestyle modification is the clinical foundation of ED treatment. Far from being a "soft" recommendation, the evidence supporting lifestyle interventions is robust:

- **Exercise**: A meta-analysis of 10 studies involving 1,300+ men found that aerobic exercise significantly improved erectile function — comparable to PDE5 inhibitor effects in mild-to-moderate ED (Silva et al., 2017, _British Journal of Sports Medicine_). The minimum effective dose: 150 minutes of moderate-intensity aerobic exercise per week.
- **Weight loss**: The landmark Esposito et al. (2004) randomized controlled trial in _JAMA_ demonstrated that 31% of obese men with ED who adopted lifestyle changes (Mediterranean diet + exercise) recovered normal erectile function at two years.
- **Smoking cessation**: Vascular improvements begin within 24 hours and continue progressively for months. Studies show measurable improvement in penile hemodynamics within 4–12 weeks (Pourmand et al., 2004, _BJU International_).
- **Diet**: The Mediterranean diet — rich in olive oil, fish, nuts, fruits, and vegetables — has been consistently associated with lower ED prevalence (Giugliano et al., 2010, _Diabetologia_).
- **Sleep optimization**: Men sleeping fewer than 5 hours per night have significantly lower testosterone levels (Leproult & Van Cauter, 2011, _JAMA_).

\> "Lifestyle optimization isn't optional — it's the foundation that makes everything else work better. A man taking Cialis while continuing to smoke, eat poorly, and sleep five hours a night is fighting with one hand tied behind his back." > — **Dr. Lloyd Tapper, PhD, NP**

### What This Looks Like at ReGenesis

Our lifestyle optimization program includes personalized exercise prescription, nutritional guidance (with specific attention to nitric oxide-boosting foods), sleep hygiene assessment, stress management strategies, and substance use counseling.

## Tier 2: Oral Pharmacotherapy — PDE5 Inhibitors

### How They Work

PDE5 inhibitors block the enzyme phosphodiesterase type 5, which degrades cyclic guanosine monophosphate (cGMP) — the molecule responsible for smooth muscle relaxation in the corpus cavernosum. By inhibiting PDE5, these medications allow cGMP to accumulate, enhancing blood flow to the penis during sexual stimulation.

**Important**: PDE5 inhibitors require sexual arousal to work. They do not cause spontaneous erections.

### Comparative Overview

| Medication | Onset | Duration | Food Interaction | Unique Advantage |
| --- | --- | --- | --- | --- |
| **Sildenafil (Viagra)** | 30–60 min | 4–6 hours | High-fat meals delay absorption | Most clinical data (25+ years) |
| **Tadalafil (Cialis)** | 30 min | Up to 36 hours | No significant food interaction | Daily low-dose option; longest duration |
| **Vardenafil (Levitra)** | 25–60 min | 4–5 hours | High-fat meals reduce absorption | Potential advantage in diabetic ED |

### Efficacy and Limitations

PDE5 inhibitors are effective in approximately **70% of men** across all ED etiologies (Hatzimouratidis et al., 2010, _European Urology_). However, response rates are lower in specific populations:

- **Diabetic men**: 56–64% response rate
- **Post-radical prostatectomy**: 35–75% depending on nerve-sparing status
- **Severe vascular disease**: Reduced efficacy due to inadequate arterial supply

### Safety Considerations

Absolute contraindications include concurrent use of nitrate medications (risk of severe hypotension) and recent cardiovascular events. Common side effects include headache (10–16%), flushing (5–12%), nasal congestion (3–6%), and — specific to sildenafil — transient blue-tinted vision.

## Tier 3: Injectable Therapies — When Pills Aren't Enough

### The Gold Standard: Trimix

Trimix (papaverine + phentolamine + alprostadil) is the most widely prescribed injectable ED therapy, with success rates exceeding **85%** — even in men who fail oral medications (Coombs et al., 2012, _Journal of Sexual Medicine_).

The injection is administered directly into the corpus cavernosum using a fine insulin-type needle. Erection onset occurs within 5–15 minutes and duration is dose-dependent (typically 30–90 minutes).

### Formulation Comparison

| Formulation | Components | Potency | Best For |
| --- | --- | --- | --- |
| **Bimix** | Papaverine + Phentolamine | Moderate | Mild-to-moderate ED beyond oral medications |
| **Trimix** | Papaverine + Phentolamine + Alprostadil | High | Most men needing injectable therapy |
| **Quadmix** | Papaverine + Phentolamine + Alprostadil + Atropine | Highest | Treatment-resistant cases |

### The ReGenesis Injectable Protocol

At our Edmonton and Calgary clinics, injectable therapy follows a structured protocol:

1. **In-office dose calibration**: Starting with a conservative test dose, titrated under medical supervision
2. **Injection technique training**: Proper site selection, needle angle, and injection depth
3. **Response monitoring**: Erection quality and duration observed to optimize dosing
4. **Home self-injection education**: Comprehensive written and verbal instructions
5. **Follow-up**: Scheduled reassessment to fine-tune dosing

\> "Many men are apprehensive about injections, but after the first in-office demonstration, the vast majority report minimal discomfort — and the reliability of the result changes their perspective entirely." > — **Dr. Lloyd Tapper, PhD, NP**

## Tier 4: Regenerative Medicine

### P-Shot (Priapus Shot) — PRP Therapy

The P-Shot uses autologous platelet-rich plasma (PRP) to stimulate angiogenesis (new blood vessel formation) and tissue regeneration in the penis. Growth factors concentrated from the patient's own blood are injected into the corpus cavernosum.

Clinical studies have shown improvements in IIEF scores following PRP therapy, with results developing over 4–12 weeks as neovascularization occurs (Epifanova et al., 2020, _Sexual Medicine Reviews_).

### Penile Botox

Botulinum toxin injected into the corpus cavernosum relaxes smooth muscle, potentially improving blood flow. While still considered investigational, early clinical data is promising, with a pilot study by Ghanem et al. (2018) showing improved IIEF scores and increased peak systolic velocity on Doppler ultrasound.

### Low-Intensity Shockwave Therapy (LiSWT)

LiSWT applies acoustic waves to the penis to promote neovascularization and recruit endothelial progenitor cells. A meta-analysis by Lu et al. (2017, _Journal of Sexual Medicine_) found significant improvement in IIEF scores compared to sham treatment, with benefits persisting at 6-month follow-up. _Please note: Shockwave therapy is not provided at ReGenesis Longevity Clinic._

## Tier 5: Penile Implants — The Definitive Solution

For men with severe, treatment-resistant ED, penile implant surgery remains the gold standard. Modern three-piece inflatable devices (e.g., Coloplast Titan, Boston Scientific AMS 700) provide on-demand rigidity with natural flaccidity between uses.

**The evidence**: - Patient satisfaction rates exceed **90%** (Bernal & Henry, 2012, _Journal of Sexual Medicine_) - Partner satisfaction rates are similarly high (85–90%) - Device longevity: 15–20 years before revision is typically needed - Infection rates with modern antibiotic-coated devices: <1%

## Choosing the Right Treatment

The optimal treatment is determined by the intersection of four factors:

1. **Etiology**: What is causing the ED?
2. **Severity**: Mild, moderate, or severe?
3. **Comorbidities**: Cardiovascular disease, diabetes, neurological conditions?
4. **Patient preference**: Spontaneity, ease of use, invasiveness tolerance?

At ReGenesis, we offer every tier of treatment — which means our recommendations are based on clinical appropriateness, not inventory limitations.

## References

1. Silva AB, et al. Physical activity and exercise for erectile dysfunction. _British Journal of Sports Medicine_. 2017;51(19):1419-1424.
2. Esposito K, et al. Effect of lifestyle changes on erectile dysfunction in obese men. _JAMA_. 2004;291(24):2978-2984.
3. Hatzimouratidis K, et al. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. _European Urology_. 2010;57(5):804-814.
4. Coombs PG, et al. A review of outcomes of an intracavernosal injection therapy programme. _BJU International_. 2012;110(11):1787-1791.
5. Lu Z, et al. Low-intensity extracorporeal shock wave treatment improves erectile function: a systematic review and meta-analysis. _European Urology_. 2017;71(2):223-233.
6. Bernal RM, Henry GD. Contemporary patient satisfaction rates for three-piece inflatable penile prostheses. _Advances in Urology_. 2012;2012:707321.

## Schedule Your Assessment

| Location | Address | Phone | Action |
| --- | --- | --- | --- |
| **Edmonton — Windermere Plaza** | 213, 5540 Windermere Blvd, Edmonton, AB T6W 2Z8 | 587.635.3414 | **Book Now →: https://regenesisformen.com/contact** |
| **Calgary — Silk Touch** | 1102, 8561 8A Ave SW, Calgary, AB T3H 0V5 | 403.454.8196 | **Book Now →: https://regenesisformen.com/contact** |

_Confidential assessments available. Same-week appointments for new patients._

### Ready to Take the Next Step?

Book a confidential assessment with a ReGenesis clinician.

Call 587.635.3414 (587.635.3414)

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